Figure 3.

N-acetylglucosamine (GlcNAc) stimulates signaling via GlcNAc sensor and transducer Ngs1. Upon GlcNAc binding, Ngs1 induces expression of GlcNAc catabolic genes (e.g., NAG1 and DAC1) [34] and filamentation regulating transcription factor, BRG1 by acetylating at their promoters [14]. Transcription factor (TF) Rep1 recruits Ngs1 to the GlcNAc catabolic gene promoters (left panel), whereas TFs recruiting Ngs1 to BRG1 promoter are yet to be found (right panel). The active relationship is represented with green lines and transcriptional promotion is represented with black arrows.