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. 2021 Jan 19;13(2):343. doi: 10.3390/cancers13020343

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Depletion of La reduces transforming growth factor β (TGFβ)-induced EMT in lung and head and neck cancer cells. La depletion blocks the TGFβ-induced transition from epithelial to mesenchymal phenotype in (A) lung adenocarcinoma A549 and (B) head and neck squamous cell carcinoma SCC22A cells (representative images of at least three independent experiments (n = 3), scale 200-fold magnification). Reduced expression of EMT marker N-cadherin in TGFβ-treated and La-depleted (C) A549 and (D) SCC22A cells. IB: immunoblot. TGFβ (plus) [5 ng/mL] or vehicle (minus) [1 mg/mL BSA in 4 mM HCl] treatment. Numbers below the bands represent the protein expression normalized to GAPDH.