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. 2021 Jan 19;13(2):343. doi: 10.3390/cancers13020343

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reduced expression of cellular markers defining EMT and cancer cell stemness in TGFβ-treated and La-depleted cells. Depletion of La reduces the expression of EMT marker ZO-1, N-cadherin, Vimentin, and ZEB1. In addition, the cancer cell stemness marker CD44 and Bmi1 are diminished in TGFβ-treated and La-depleted SCC22A cells. IB: immunoblot. TGFβ (plus) [5 ng/mL] or vehicle (minus) [1 mg/mL BSA in 4 mM HCl] treatment. Numbers below the bands represent the protein expression normalized to GAPDH.