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Depletion of La reduces SCC sphere formation and growth. Control- (shCon) or La-depleted (shLa1, shLa2) SCC22A cells were plated in a serum-free medium plus TGFβ [5 ng/mL] on ultra-low attachment plates. (A) Representative phase contrast images of spheres, 50-fold magnification. (B) Number and (C) size of spheres were analyzed after 6 days (p value < 0.005 (two asterisks), p value < 0.001 (three asterisks), n = 3).
