Table 3.

List of neutralizing monoclonal antibody and protease inhibitors

S.N.	Name	Experimental model	Mechanism	References
1	Anti-ACE2	Mouse	Target the spike protein of SARS-CoV-2 that inhibits virus binding cell receptors	Shanmugaraj et al. (2020)
2	CR3014	Ferret and in vitro	Binding to the 318–510 amino acid residues with high affinity on S1 fragment of SARS-CoV andblock the interaction of S1 subunit protein with cellular receptor ACE2 in vitro and in vivo	van den Brink et al. (2005), ter Meulen et al. (2006), Jan ter Meulen et al. (2004)
3	CR3022	In vitro	Binding to the 318–510 amino acid residues on S1 fragment of SARS-CoVand block the interaction of S1 subunit protein with cellular receptor ACE2	ter Meulen et al. (2006)
4	F26G18	In vitro	Binding to the linear epitope460-476amino acid residues on S1 fragment of SARS-CoVand block the interaction of S1 subunit protein with cellular receptor ACE2	Berry et al. (2010)
5	F26G19	In vitro	Binding to the conformational epitope (amino acid residues 359–362, 391–392, 424–427, and 486–492) on S1 fragment of SARS-CoVand block the interaction of S1 subunit protein with cellular receptor ACE2	Berry et al. (2010)
6	m396	In vitro	Binding to the conformational epitope amino acid residues 482–491 on S1 fragment of SARS-CoV and block the interaction of S subunit protein using CDR loops H1, H2, H3, and L3 with cellular receptor ACE2	Berry et al. (2010), Zhu et al. (2007)
7	1A9	In vitro	Binding to the Heptad repeat loops, including heptad repeat one and heptad repeat one domain on S2 fragmentof SARS-CoV and block the interaction of S2 subunit protein with cellular receptorACE2	Ng et al. (2014), Lip et al. (2006)
8	201	Mouse Syrian Hamster and in vitro	Binding to the 490–510 amino acid residues on S1 fragment of SARS-CoV and block the interaction of S1 subunit protein with cellular receptor ACE2 in vitro and in vivo	Greenough et al. (2005), Coughlin and Prabhakar (2012)
9	4D4	in vitro	Binding to the 12–261 amino acid residues of SARS-CoV and N-terminal of RBD and Inhibit the post-interaction in the viral permeation	Coughlin and Prabhakar (2012), Elshabrawy et al. (2012)
10	S230	in vitro	Binding to epitopes partially overlapping with receptor binding motifs on B domain of SARS-CoVand block the interaction of S1 subunit protein with cellular receptor ACE2 in vitro	Walls et al. (2019)