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. 2020 Dec 15;120(9):1706–1718. doi: 10.1016/j.jfma.2020.12.003

Table 6.

Meta-Analysis outcomes for COVID-19 patients (random-effects model) (N = 35).

Item No. of studies Prevalence% 95% CI n I2 T2 P-value for testing heterogeneity. Egger's test P
Demographical characteristics
Age (mean in years) 21 46.8 41.0–52.6 20 99.78 180.467 <0.001 0.0438
Male 33 54.0 51.3–56.7 32 69.535 0.040 <0.001 0.0189
Co-Morbidities
Co-morbidities 17 29.5 19.0–36.6 16 98.738 1.372 <0.001 0.8677
DM 17 13.8 8.7–21.1 17 96.645 1.076 <0.001 0.0183
Hypertension 15 11.7 5.7–22.6 14 98.66 2.241 <0.001 0.0025
CVD 16 9.7 6.5–14.2 15 92.455 9.639 <0.001 0.0441
COPD 14 3.9 2.9–5.3 13 62.282 0.132 <0.001 0.1004
Clinical manifestations
Fever 31 82.0 67.7–90.8 30 98.557 4.531 <0.001 0.0117
Cough 29 54.3 45.5–62.9 28 93.792 0.779 <0.001 0.0090
Fatigue 21 30.2 23.3–38.1 20 83.651 0.465 <0.001 0.9873
Sputum 13 28.5 21.2–37.2 12 83.783 0.390 <0.001 0.7643
Sore Throat 10 21.7 14.6–31.0 9 74.296 0.338 <0.001 0.3871
Headache 13 11.0 7.9–15.2 12 68.412 0.227 <0.001 0.4517
Hemoptysis 3 5.3 3.0–8.9 2 0 0 0.424 0.1580
Laboratory findings
Leukocytosis 16 7.5 4.5–12 15 85.716 0.842 <0.001 0.0093
Leukopenia 17 16.0 9.5–25.7 16 93.670 1.342 <0.001 0.2359
Lymphopenia 17 41.9 30.1–54.7 16 97.302 1.074 <0.001 0.0956
High Creatinine 7 7.7 3.2–17.3 6 86.947 1.135 <0.001 0.1139
High LDH 10 51.5 40.3–62.6 9 94.679 0.463 <0.001 0.0074
CRP 12 48.1 29.8–66.9 11 96.494 1.622 <0.001 0.0215
ESR 4 23.5 11.1–42.9 3 79.739 0.752 0.002 0.0214
Complications
RNA Anemia 13 98.2 96.2–99.2 12 0 0 0.974 0.0001
Hospitalization 23 83.7 76.0–89.3 22 89.67 0.784 <0.001 0.0613
Bilateral Pneumonia 19 70.9 58.2–81.0 18 92.552 1.207 <0.001 0.0485
Unilateral Pneumonia 15 26.2 14.6–42.2 14 91.829 1.723 <0.001 0.2087
ARDS 6 23.6 12.9–39.2 5 91.623 0.703 <0.001 0.7139
Shock 7 8.5 4.4–10.8 6 74.476 0.516 <0.001 0.0254
Discharge 16 43.5 24.9–64.2 15 98.13 2.84 <0.001 0.8226
Death 17 10.5 6.8–16.1 16 94.32 0.816 <0.001 0.0214

No, number; CI, confidence interval; DM, diabetes mellitus; CVD, cardiovascular disease; COPD, chronic obstructive pulmonary disease ICU, intensive care unit. LDH, lactate dehydrogenase; ARDS, acute respiratory distress syndrome; CRP, C-reactive protein.

Q Cochran's Q statistic for heterogeneity. n, degree of freedom, I2 Index for the degree of heterogeneity. T2 Tau-squared measure of heterogeneity.