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Pathogenetic mechanisms of primary myelofibrosis and cell lines involved: summary panel. Bone marrow dysregulations due to the neoplastic expansion of one hematopoietic stem cell produce a number of events that took place within the pathological microenvironment. The most relevant clinical consequences are neoangiogenesis, megakaryocytes hyperplasia and extensive bone marrow fibrosis, followed by osteosclerosis and bone damage.
