Supplement Table 1.

Example of recommendations for antibiotics and antifungal drugs

Antibiotics and antifungal drugs	Recommendation examples
Treatment effectiveness
Drug selection	A patient had gram-positive bacteria isolated from throat swabs, rising CRP, and CRRT treatment. Linezolid (0.6g q12h) was recommended for with (accepted).
Dose selection	A patient had less than 0.5 μg/ml blood concentration of voriconazole. Increasing the dose of voriconazole to 200 mg q8h was advised (accepted).
Treatment duration	A patient achieved near-normal indicators of bacterial infections. Considering the lack of evidence supporting infections caused by Gram positive bacteria, discontinuation of daptomycin was advised (accepted).
Adverse drug event occurring
Drug selection
Liver function	The blood concentration of voriconazole was 5.6 μg/ml for a patient whose TBL was 101.8 μmol/L. Adjustment of antifungal drugs was recommended (voriconazole ➝ micafungin 150 mg qd, accepted).
Central nervous system	A patient developed psychiatric symptoms, which may be caused by imipenem/cilastatin. Adjustment of antibiotics was recommended (imipenem/cilastatin ➝ cefoperazone/sulbactam 2g q8h, accepted).
Cardiovascular system	A patient with CRRT treatment developed arrhythmia and abnormal TBL, which may be caused by levofloxacin. Discontinuation of levofloxacin was recommended.
Skin	A patient developed skin rashes over the whole body, which may be caused by drugs. Discontinuation of caspofungin, linezolid, montelukast and olanzapine was recommended (accepted).
Urinary system	The Scr elevated to 143 μmol/L in a patient, which may be caused by teicoplanin. Discontinuation of teicoplanin was recommended.
Dose selection	The blood concentration of vancomycin was 33.34 μg/ml in a patient with hemodialysis treatment due to renal function failure. Discontinuation of vancomycin was recommended (accepted).
Treatment duration	The Scr was 129 μmol/L for a patient with polymyxin B treated for 2 weeks. Discontinuation of polymyxin B was recommended.