Treatment effectiveness |
Drug selection |
A patient with positive SARS-CoV-2 RNA received arbidol alone. Lopinavir/ritonavir combined with arbidol was proposed (accepted). |
Adverse drug event occurring |
Drug selection |
Abnormal liver function risks |
A patient had elevated ALT (114 U/L) and AST (236 U/L), which may be caused by darunavir/cobicistat. Discontinuation of darunavir/cobicistat was recommended (accepted). |
Cardiovascular system risks |
A patient had temporary sinus bradycardia, which may be caused by arbidol and should be closely monitored (accepted). |
Drug-drug interactions |
Serious drug-drug interaction exists between quetiapine and lopinavir/ritonavir. Discontinuation of darunavir/cobicistat was recommended (accepted). |
Dose selection |
A patient had 33.34 μg/ml blood concentration of vancomycin and received hemodialysis treatment due to renal function failure. Discontinuation of vancomycin was recommended (accepted). |
Treatment duration |
Three consecutive negative results with qPCR detection over an interval of 24 h. Discontinuation of favipiravir and arbidol was recommended (accepted). |