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. 2020 Jun 6;17(1):1853–1858. doi: 10.1016/j.sapharm.2020.06.005

Table 3.

Example of recommendations for antiviral regiments.

Antiviral treatment Recommendation examples
Treatment effectiveness
Drug selection A patient with positive SARS-CoV-2 RNA received arbidol alone. Lopinavir/ritonavir combined with arbidol was proposed (accepted).
Adverse drug event occurring
Drug selection
 Abnormal liver function risks A patient had elevated ALT (114 U/L) and AST (236 U/L), which may be caused by darunavir/cobicistat. Discontinuation of darunavir/cobicistat was recommended (accepted).
Cardiovascular system risks A patient had temporary sinus bradycardia, which may be caused by arbidol and should be closely monitored (accepted).
 Drug-drug interactions Serious drug-drug interaction exists between quetiapine and lopinavir/ritonavir. Discontinuation of darunavir/cobicistat was recommended (accepted).
Dose selection A patient had 33.34 μg/ml blood concentration of vancomycin and received hemodialysis treatment due to renal function failure. Discontinuation of vancomycin was recommended (accepted).
Treatment duration Three consecutive negative results with qPCR detection over an interval of 24 h. Discontinuation of favipiravir and arbidol was recommended (accepted).