Figure 2.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) inhibition of contrast-induced acute kidney injury decreases the levels of renal injury biomarkers. (A) Arachidonic acid prostaglandin biosynthesis pathway and the biological activity of 15-PGDH inhibitor (SW033291). (B) Prostaglandin E₂ (PGE2) levels in kidney tissue 1 h after intraperitoneal injection of 5 mg/kg SW033291 or a vehicle. (C) Experimental setup: mice received SW033291, PGE1, PGE2, or vehicle at 1 h before, immediately after, and 8, 16, and 24 h after administration of 10 gI/kg iodixanol. (D–F) Serum levels of creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1), respectively. Renal function was evaluated at 48 h after contrast medium (CM) injection. *p < 0.05; **p < 0.01; ***p < 0.001.