Table 2.
Subgroup analyses.
| Parameters | Factors | Subgroup | Effect estimate and 95%CI | I2 (%) | p Value for Q statistic | Ratio between subgroups | p Value between subgroups |
|---|---|---|---|---|---|---|---|
| Sensitivity | Country | Europe | 0.67 (0.32–0.90) | 83.4 | <.01 | 1.00 (0.59–1.69) | 1.000 |
| Asia | 0.67 (0.60–0.74) | 29.5 | .21 | ||||
| Mean age (years) | ≥50.0 | 0.53 (0.42–0.63) | 47.5 | .13 | 0.78 (0.62–0.98) | .032 | |
| <50.0 | 0.68 (0.61–0.75) | 38.3 | .17 | ||||
| Percentage male (%) | ≥65.0 | 0.67 (0.58–0.75) | 66.7 | .01 | 1.24 (0.90–1.72) | .193 | |
| <65.0 | 0.54 (0.38–0.69) | 65.7 | .03 | ||||
| Study quality | High | 0.69 (0.45–0.85) | 80.1 | <.01 | 1.15 (0.80–1.66) | .452 | |
| Low | 0.60 (0.49–0.70) | 0.0 | .51 | ||||
| Specificity | Country | Europe | 0.65 (0.32–0.88) | 76.0 | .01 | 0.79 (0.47–1.34) | .389 |
| Asia | 0.82 (0.67–0.91) | 80.2 | <.01 | ||||
| Mean age (years) | ≥50.0 | 0.62 (0.24–0.89) | 76.6 | .01 | 0.72 (0.37–1.39) | 0.331 | |
| <50.0 | 0.86 (0.79–0.91) | 48.0 | .10 | ||||
| Percentage male (%) | ≥65.0 | 0.67 (0.43–0.85) | 84.7 | <.01 | 0.78 (0.55–1.10) | .161 | |
| <65.0 | 0.86 (0.78–0.91) | 38.1 | .18 | ||||
| Study quality | High | 0.81 (0.71–0.88) | 68.5 | .01 | 1.04 (0.53–2.02) | .912 | |
| Low | 0.78 (0.26–0.97) | 88.4 | <.01 | ||||
| PLR | Country | Europe | 1.93 (0.67–5.56) | 72.0 | <.01 | 0.52 (0.15–1.83) | .308 |
| Asia | 3.72 (1.87-7.38) | 71.1 | <.01 | ||||
| Mean age (years) | ≥50.0 | 1.38 (0.46–4.12) | 15.5 | .06 | 0.29 (0.09–0.94) | .038 | |
| <50.0 | 4.79 (3.12–7.36) | 4.2 | .08 | ||||
| Percentage male (%) | ≥65.0 | 2.02 (0.95–4.28) | 79.8 | <.01 | 0.53 (0.21–1.35) | .185 | |
| <65.0 | 3.78 (2.20–6.50) | 11.9 | .07 | ||||
| Study quality | High | 3.54 (2.35–5.32) | 12.5 | .05 | 1.32 (0.19–9.03) | .780 | |
| Low | 2.69 (0.41–17.70) | 79.6 | <.01 | ||||
| NLR | Country | Europe | 0.50 (0.16–1.58) | 79.7 | <.01 | 1.25 (0.38–4.07) | .711 |
| Asia | 0.40 (0.30–0.53) | 63.8 | .02 | ||||
| Mean age (years) | ≥50.0 | 0.77 (0.37–1.60) | 77.2 | <.01 | 2.08 (0.96–4.50) | .062 | |
| <50.0 | 0.37 (0.29–0.47) | 57.1 | .05 | ||||
| Percentage male (%) | ≥65.0 | 0.50 (0.29–0.84) | 78.6 | <.01 | 0.94 (0.49–1.80) | 0.860 | |
| <65.0 | 0.53 (0.37–0.77) | 66.8 | .03 | ||||
| Study quality | High | 0.39 (0.20–0.73) | 73.5 | <.01 | 0.75 (0.29–1.92) | .548 | |
| Low | 0.52 (0.26–1.01) | 79.3 | <.01 | ||||
| DOR | Country | Europe | 3.57 (0.35–36.20) | 81.0 | <.01 | 0.46 (0.04–5.85) | .553 |
| Asia | 7.68 (2.78–21.24) | 73.2 | <.01 | ||||
| Mean age (years) | ≥50.0 | 1.19 (0.32–4.38) | 62.0 | .05 | 0.11 (0.02–0.50) | .004 | |
| <50.0 | 11.06 (4.97–24.59) | 50.8 | .09 | ||||
| Percentage male (%) | ≥65.0 | 5.20 (1.09–24.77) | 85.9 | <.01 | 0.81 (0.11–5.94) | .835 | |
| <65.0 | 6.43 (1.86–22.22) | 63.1 | .04 | ||||
| Study quality | High | 7.81 (3.06–19.95) | 65.9 | .01 | 2.26 (0.22–23.19) | .493 | |
| Low | 3.46 (0.41–29.20) | 83.6 | <.01 | ||||
| AUC | Country | Europe | 0.71 (0.67–0.75) | – | – | 0.97 (0.90–1.05) | .492 |
| Asia | 0.73 (0.68–0.76) | – | – | ||||
| Mean age (years) | ≥50.0 | 0.55 (0.50–0.59) | – | – | 0.71 (0.64–0.77) | <.001 | |
| <50.0 | 0.78 (0.74–0.81) | – | – | ||||
| Percentage male (%) | ≥65.0 | 0.70 (0.66–0.74) | – | – | 0.81 (0.76–0.87) | <.001 | |
| <65.0 | 0.86 (0.82–0.88) | – | – | ||||
| Study quality | High | 0.83 (0.79–0.86) | – | – | 1.32 (1.22–1.42) | <.001 | |
| Low | 0.63 (0.59–0.67) | – | – |