Fig. 4.

GSEA (R implementation) based identification of ACE2 expression-specific pathways. A. KEGG pathways enriched in TCGA-LUAD (NES>0 is enriched in high expression group and NES<0 is enriched in low expression group). B. KEGG pathways enriched in GSE40791 (No pathways found in low expression group of ACE2) (P < 0.05). C. Correlation between the pathway enrichment score (ssGSEA) and the expression level of ACE2. upregulated overlapping 13 pathways have direct positive correlations with the expression of ACE2 across the datasets (Spearman's correlation test, P < 0.05).