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. 2021 Jan 7;335:109370. doi: 10.1016/j.cbi.2021.109370

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Fig. 6 — Module coexpression networks of ACE2 in lung adenocarcinoma. A. WGCNA based identification of gene modules (gene ontology) more highly enriched in high-ACE2-expression-level and low-ACE2-expression-level in TCGALUAD cohorts. B. A subnetwork of the green-yellow gene module active in the high-ACE2-expression-level group of TCGA-LUAD. GCLC and SLC7A11 (indicated blue color) hub genes are associated with survival prognosis. C.GCLC and SLC7A11 hub genes are significantly highly expressed in GTEx combined with TCGA-LUAD cohorts. D. Kaplan-Meier curves shows that the elevated expression of GCLC and SLC7A11 hub genes are associated with a worse overall survival (OS) prognosis in TCGA-LUAD cohorts by GEPIA 2 (log-rank test, P < 0.05). E. Kaplan-Meier curves also show that GCLC and SLC7A11 hub genes are associated with shorter survival prognosis (OS) in GSE13213 dataset by Prognoscan (log-rank test, P < 0.05).