Table 2.
List of anti-SARS-CoV compounds from natural sources with unidentified mechanism of action.
| Compound | Class | Source | Biological action/Efficacy | Experiment | Reference |
|---|---|---|---|---|---|
| Cinnamtannin B1 | Flavonoid | Cinnamomi cortex | IC50 = 32.9 μM (HIV/SARS-CoV S pseudovirus) | Cell-based assay (Luciferase reporter assay) | 46 |
| IC50 = 32.9 μM (Wild-type SARS-CoV) | Cell-based assay (Plaque reduction assay) | ||||
| Lycorine | Crystalline alkaloid | Lycoris radiata | IC50 = 15.7 nM | Cell-based assay (CPE/MTS assay) | 121 |
| Procyanidin A2 | Flavonoid | Cinnamomi cortex | IC50 = 120.7 μM (HIV/SARS-CoV S pseudovirus) | Cell-based assay (Luciferase reporter assay) | 46 |
| IC50 = 29.9 μM (Wild-type SARS-CoV) | Cell-based assay (Plaque reduction assay) | ||||
| Procyanidin B1 | Flavonoid | Cinnamomi cortex | IC50 = 161.1 μM (HIV/SARS-CoV S pseudovirus) | Cell-based assay (Luciferase reporter assay) | 46 |
| IC50 = 41.3 μM (Wild-type SARS-CoV) | Cell-based assay (Plaque reduction assay) |
CPE/MTS = cytopathic effect-based MTS reduction; IC50 = the half maximal inhibitory concentration.
(a) The study used commercial products. Here provides a natural source of compound as an example.