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. 2021 Jan 25;16(1):e0245831. doi: 10.1371/journal.pone.0245831

Table 1. Genotypes of all PAH-targeted piglets.

Pig ID Breed Lifespan Genotype
Pregnancy A
1769 Ossabaw 4 days hR408W Homozygote
Pregnancy B
1794 Yorkshire 5 days hR408W Homozygote
1795 Yorkshire 2 days hR408W Homozygote
1796 Yorkshire 2 days hR408W Homozygote
1797 Yorkshire 3 days hR408W Homozygote
Pregnancy C
1798 Yorkshire 5 days hR408W Homozygote
Pregnancy D (NTBC)
21 (still born) Yorkshire 0 days hR408W Homozygote
22 Charm Yorkshire 6 days Compound Heterozygote—hR408W; pA403GfsX471
23 Lucky Yorkshire 200 days§ Compound Heterozygote—hR408W; pA403GfsX471
Pregnancy E (NTBC)
899 Cornflake Yorkshire 96 days hR408W/R408W compound heterozygote- one allele lacks the two 5’ humanized bases2
900 Cheerio Yorkshire 2 days hR408W/R408W compound heterozygote- one allele lacks the two 5’ humanized bases2

§ Pig No. 23 is still alive as of the preparation of this manuscript.

1 A frame-shifting indel introduces a stop codon 47 amino acids downstream in A403GfsX47 (sequence presented Fig 2)

2 Incompletely humanized R408W.