Table 1. Genotypes of all PAH-targeted piglets.
Pig ID | Breed | Lifespan | Genotype |
---|---|---|---|
Pregnancy A | |||
1769 | Ossabaw | 4 days | hR408W Homozygote |
Pregnancy B | |||
1794 | Yorkshire | 5 days | hR408W Homozygote |
1795 | Yorkshire | 2 days | hR408W Homozygote |
1796 | Yorkshire | 2 days | hR408W Homozygote |
1797 | Yorkshire | 3 days | hR408W Homozygote |
Pregnancy C | |||
1798 | Yorkshire | 5 days | hR408W Homozygote |
Pregnancy D (NTBC) | |||
21 (still born) | Yorkshire | 0 days | hR408W Homozygote |
22 Charm | Yorkshire | 6 days | Compound Heterozygote—hR408W; pA403GfsX471 |
23 Lucky | Yorkshire | 200 days§ | Compound Heterozygote—hR408W; pA403GfsX471 |
Pregnancy E (NTBC) | |||
899 Cornflake | Yorkshire | 96 days | hR408W/R408W compound heterozygote- one allele lacks the two 5’ humanized bases2 |
900 Cheerio | Yorkshire | 2 days | hR408W/R408W compound heterozygote- one allele lacks the two 5’ humanized bases2 |
§ Pig No. 23 is still alive as of the preparation of this manuscript.
1 A frame-shifting indel introduces a stop codon 47 amino acids downstream in A403GfsX47 (sequence presented Fig 2)
2 Incompletely humanized R408W.