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. 2021 Jan 25;16(1):e0245171. doi: 10.1371/journal.pone.0245171

Fig 2. Pre-treatment with manganese induces proliferation and inflammatory activation in astrocytes in the substantia nigra following infection with H1N1.

Fig 2

(A-D) IF labeling of astrocytes (s100β). Groups: Control, Mn, H1N1, H1N1+ MnCl2. (E) Cell counts of the s100β+ astrocytes in the substantia nigra pars compacta (SNpc). (F-I) IF colocalization of astrocytes (s100β) with complement C3 (C3). (J) C3 mean intensity measurements in s100β+ astrocytes in the SNpc. (K-N) IF colocalization of astrocytes (s100β) with SerpinA3. (O) SerpinA3 mean intensity measurements in S100β+ astrocytes in the SNpc. (P-S) IF colocalization of astrocytes (s100β) with complement IP-10/Cxcl10 (IP-10). (T) IP-10 mean intensity measurements in s100β+ astrocytes in the SNpc. (U-X) IF colocalization of astrocytes (s100β) with complement Ccl2. (J) Ccl2 mean intensity measurements in s100β+ astrocytes in the SNpc. *P<0.05 **P<0.01 ***P<0.001****P<0.0001. n = 6 mice/group.