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Pharmacokinetics and toxicity properties of the three potential inhibitors.
| Ligand | Ames_test | Carcino_Rat | BBB permeant | hERG | P-gp S. | Inhibition Constant (nM) | 1A2 | 2C19 | 2C9 | 2D6 | 3A4 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | Mutagen | Positive | No | Low risk | No | 3.19 | No | No | No | No | No |
| 1 | Non-mutagen | Negative | No | Ambiguous | Yes | 22.53 | No | No | No | No | No |
| 8 | Non-mutagen | Negative | No | High risk | Yes | 27.80 | No | No | No | No | Yes |
