Fig. 1.

TCR clonal expansion of COVID-19 and normal samples. a. The TCR distribution of COVID-19 patients and healthy controls. Unique (n = 1), duplicated (n = 2), and clonal (n ≥ 3) TCRs are labeled with different colors. b. The CDR3β aa length distribution of clonally expended TCRs in COVID-19 patients and healthy controls. c. Box plot shows that the clonal diversity of COVID-19 is significantly lower than that of healthy controls. Each dot represents the clonal diversity of each sample. p-value was calculated using the Mann-Whitney U test. d. Venn diagram shows the common and specific TCR numbers of COVID-19 patients and healthy controls. Bar plots show the distribution of COVID-19 specific clonotypes (top right) and the distribution of COVID-19 specific clonally expanded clonotypes (bottom right).