Fig. 2.

TCR variable (V) and joining (J) gene usage comparison between COVID-19 patients and healthy controls. a. The frequency and differential analysis of V and J gene segments of alpha and beta chains. P < 0.05, Fisher's exact test. b. Venn diagram shows the common and specific VJ gene pairs of COVID-19 patients and healthy controls. Pie charts show the proportion of cells that harbored common VJ pairs in COVID-19 patients (right) and healthy controls (left). c. Volcano plots show common TRAVJ (left) and TRBVJ (right) pairs. Red dots represent significantly increased and blue dots represent significantly decreased in VJ pairs frequency of COVID-19 patients compared to healthy controls. d. Circos plots show the specific and differential TRAVJ (left) and TRBVJ (right) pairs in COVID-19 patients. e. Sankey diagram shows COVID-19 specific αβ VJ pairs that occurred more than once. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)