Table 1.

Diarylureas as antiparasitic agents.

Structure	Compd	Activity	Ref
Antiparasitic agents
	MMV665852	IC50 = 4.7 µM (S. mansoni NTS) IC50 = 0.8 µM (adult S. mansoni) IC50 = 4.4 µM (juvenile S. japonicum) IC50 = 2.2 µM (adult S. japonicum)	[47] [49]
	Triclocarban (TCC)	IC50 = 0.07 µM (S. mansoni NTS) IC50 = 0.4 µM (adult S. mansoni)	[48]
	1	IC50 = 1.3 µM (S. mansoni NTS) IC50 = 0.7 µM (adult S. mansoni)	[48]
	2	IC50 = 0.2 µM (adult S. mansoni)	[48]
	3	IC50 = 3.6 µM (adult S. mansoni)	[48]
	4	IC50 = 7.0 µM (adult S. mansoni)	[48]
	5	IC50 = 2.5 µM (juvenile S. japonicum) IC50 = 1.5 µM (adult S. japonicum)	[49]
	6 (Flucofuron)	IC50 = 2.8 µM (juvenile S. japonicum) IC50 = 1.5 µM (adult S. japonicum)	[49]
	7	IC50 = 0.15 µM (S. mansoni NTS) IC50 = 0.19 µM (adult S. mansoni)	[19]
	Sorafenib (BAY-43-9006)	IC50 = 4.1 µM (S. mansoni NTS) IC50 = 1.1 µM (adult S. mansoni)	[54]
	Regorafenib (BAY-73-4506)	IC50 = 6.9 µM (S. mansoni NTS) IC50 = 1.0 µM (adult S. mansoni)	[54]