Table 2.

Comparative Analysis of Binary Classification Tests ¹.

Test	Patients with “Definitive” PyVN N 2	Patients with “Definitive” PyVN -and- Positive Test 3 N	Sensitivity (%)	Patients without “Definitive” PyVN N	Patients without “Definitive” PyVN -and- Negative Test 4 N	Specificity (%)
Urine cytology/Decoys
≥2 tests with ≥10 cells	60	30	50	114	62	54
BKPy-viremia by PCR
≥104 viral copies/mL	61	40	66	102	82	80
≥250 viral copies/mL	61	59	97	102	33	32
Urinary PyV-Haufen	64	64	100	118	116	98

¹ Cohort is limited to 182 patients with available PyV-Haufen test results -plus- either additional test results for decoy cell shedding and/or BKPy-viremia. The overall prevalence of PyVN in this cohort is 35%. ² A patient is listed as “positive” if ≥ two samples tested positive for decoy cell shedding above threshold or ≥ one sample tested positive for BKPy-viremia above threshold or ≥ one sample tested positive for PyV-Haufen shedding. All test results collected between transplantation and index biopsy were considered in the group of 64 PyVN patients. ³ A patient is listed as “negative” if all available test results were negative or below threshold. ⁴ All test results collected within 74 weeks post transplantation were considered in the group of 118 patients without “definitive” PyVN.