Table 3.

Results for candidate SNPs.

Meta-Analysis (CAMP, CARE, LODO)																Candidate GENES
Chr	Gene/Nearest Gene	Position/rs#	n	MAF CAMP	MAF CARE	MAF LODO	Beta CAMP	SE CAMP	Beta CARE	SE CARE	Beta LODO	SE LODO	A1	Z-Score	p	Position/rs#	A1	MAF	Beta	p
1	PAPPA2	176695479/rs77977790	892	5.9%	6.8%	6.0%	−0.3	0.6	0.7	0.6	0.1	0.2	T	−0.4	0.7	176695479/rs77977790	-	2.8%	9.5	5 × 10−10	*
2	SPATS2L/KCTD18	201354935/rs3795969	892	41.6%	37.8%	36.1%	0.2	0.3	−0.7	0.3	0.1	0.1	C	0.2	0.9	201354866/rs10203042	-	2.1%	4.1	2 × 10−3	*
3	THRB	24573150/rs73038406	766	2.4%	3.2%	0.8%	−1.7	1.0	0.6	0.7	NA	NA	T	−1.0	0.3	24573150/rs73038406	-	1.5%	−4.0	0.01	*
5	ADRB2	148162955/rs10476900	892	3.0%	2.9%	2.4%	1.6	1.0	2.7	1.1	0.1	0.3	A	−2.6	9 × 10−3	148162955/rs10476900	-	10.3%	1.3	0.04	*
6	intergenic	28619532/rs116551936	892	1.6%	1.5%	1.2%	−0.9	1.3	1.6	1.1	0.1	0.4	A	0.3	0.8	28619532/rs116551936	-	0.3%	27.0	6 × 10−9	*
6	ARG1	131891820/rs2781659	892	32.5%	31.3%	31.3%	−0.1	0.3	0.1	0.3	−0.1	0.1	A	0.4	0.7	131891820/rs2781659	A	-	-	5 × 10−4	♦
6	IGF2R	160429357/rs8191725	892	2.9%	2.9%	3.2%	−0.5	1.0	1.1	1.0	−0.1	0.3	A	0.0	1.0	160429357/rs8191725	-	0.8%	10.2	3 × 10−9	*
7	CRHR2	30719049/rs1003929	892	15.9%	14.3%	12.7%	0.7	0.4	−0.3	0.4	0.1	0.1	T	1.2	0.2	30719049/rs1003929	C	-	-	0.01	♦
10	CREM	35429825/rs10827492	892	36.3%	33.5%	36.1%	0.9	0.3	0.0	0.3	0.0	0.1	T	2.3	2 × 10−2	35429825/rs10827492	C	-	-	0.05	♦
11	SPON1	14085131/rs77149876	686	0.6%	0.2%	1.2%	−0.2	2.2	NA	NA	0.4	0.4	T	−0.3	0.7	14085131/rs77149876	-	0.2%	32.5	1 × 10−8	*
11	intergenic	96962052/rs74973995	892	1.6%	1.7%	0.8%	−0.4	1.1	0.9	1.4	0.0	0.4	A	0.0	1.0	96962052/rs74973995	-	0.2%	32.6	1 × 10−8	*
12	CREBL2	12796872/rs4555	892	55.8%	54.9%	57.1%	−0.4	0.3	0.3	0.3	−0.1	0.1	T	0.9	0.4	12796872/rs4555	A	-	-	0.05	♦
12	CPM	69309377/rs1144961	892	25.4%	24.8%	25.8%	−0.3	0.4	−0.3	0.4	0.1	0.1	A	−0.7	0.5	69309377/rs1144961	G	-	-	0.05	♦
14	SLC24A4	92960148/rs4900131	892	14.9%	13.1%	17.9%	−0.6	0.4	−0.4	0.5	0.0	0.1	T	−1.7	0.1	92959857/rs77441273	-	0.2%	23.6	4 × 10−10	*
16	ADCY9	4192082/rs7201216	892	4.6%	3.2%	3.2%	0.5	0.7	0.9	1.0	−0.1	0.3	A	−0.9	0.4	4191522/rs144315541	-	0.7%	−6.7	4 × 10−4	*
20	NCOA3	46282645/rs72646209	766	0.5%	1.7%	0.4%	−3.9	2.1	−2.9	1.9	NA	NA	A	−2.4	2 × 10−2	46282708/rs115501901	-	0.2%	31.5	4 × 10−8	*

Note that the allele, MAF, and Beta were not available in all candidate published papers. * SNP from Drake et al. 2014 [15] and ♦ SNP from Litonjua et al. 2008 [9]