Table 3.
Results for candidate SNPs.
Meta-Analysis (CAMP, CARE, LODO) | Candidate GENES | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chr | Gene/Nearest Gene | Position/rs# | n | MAF CAMP | MAF CARE | MAF LODO | Beta CAMP | SE CAMP | Beta CARE | SE CARE | Beta LODO | SE LODO | A1 | Z-Score | p | Position/rs# | A1 | MAF | Beta | p | |
1 | PAPPA2 | 176695479/rs77977790 | 892 | 5.9% | 6.8% | 6.0% | −0.3 | 0.6 | 0.7 | 0.6 | 0.1 | 0.2 | T | −0.4 | 0.7 | 176695479/rs77977790 | - | 2.8% | 9.5 | 5 × 10−10 | * |
2 | SPATS2L/KCTD18 | 201354935/rs3795969 | 892 | 41.6% | 37.8% | 36.1% | 0.2 | 0.3 | −0.7 | 0.3 | 0.1 | 0.1 | C | 0.2 | 0.9 | 201354866/rs10203042 | - | 2.1% | 4.1 | 2 × 10−3 | * |
3 | THRB | 24573150/rs73038406 | 766 | 2.4% | 3.2% | 0.8% | −1.7 | 1.0 | 0.6 | 0.7 | NA | NA | T | −1.0 | 0.3 | 24573150/rs73038406 | - | 1.5% | −4.0 | 0.01 | * |
5 | ADRB2 | 148162955/rs10476900 | 892 | 3.0% | 2.9% | 2.4% | 1.6 | 1.0 | 2.7 | 1.1 | 0.1 | 0.3 | A | −2.6 | 9 × 10−3 | 148162955/rs10476900 | - | 10.3% | 1.3 | 0.04 | * |
6 | intergenic | 28619532/rs116551936 | 892 | 1.6% | 1.5% | 1.2% | −0.9 | 1.3 | 1.6 | 1.1 | 0.1 | 0.4 | A | 0.3 | 0.8 | 28619532/rs116551936 | - | 0.3% | 27.0 | 6 × 10−9 | * |
6 | ARG1 | 131891820/rs2781659 | 892 | 32.5% | 31.3% | 31.3% | −0.1 | 0.3 | 0.1 | 0.3 | −0.1 | 0.1 | A | 0.4 | 0.7 | 131891820/rs2781659 | A | - | - | 5 × 10−4 | ♦ |
6 | IGF2R | 160429357/rs8191725 | 892 | 2.9% | 2.9% | 3.2% | −0.5 | 1.0 | 1.1 | 1.0 | −0.1 | 0.3 | A | 0.0 | 1.0 | 160429357/rs8191725 | - | 0.8% | 10.2 | 3 × 10−9 | * |
7 | CRHR2 | 30719049/rs1003929 | 892 | 15.9% | 14.3% | 12.7% | 0.7 | 0.4 | −0.3 | 0.4 | 0.1 | 0.1 | T | 1.2 | 0.2 | 30719049/rs1003929 | C | - | - | 0.01 | ♦ |
10 | CREM | 35429825/rs10827492 | 892 | 36.3% | 33.5% | 36.1% | 0.9 | 0.3 | 0.0 | 0.3 | 0.0 | 0.1 | T | 2.3 | 2 × 10−2 | 35429825/rs10827492 | C | - | - | 0.05 | ♦ |
11 | SPON1 | 14085131/rs77149876 | 686 | 0.6% | 0.2% | 1.2% | −0.2 | 2.2 | NA | NA | 0.4 | 0.4 | T | −0.3 | 0.7 | 14085131/rs77149876 | - | 0.2% | 32.5 | 1 × 10−8 | * |
11 | intergenic | 96962052/rs74973995 | 892 | 1.6% | 1.7% | 0.8% | −0.4 | 1.1 | 0.9 | 1.4 | 0.0 | 0.4 | A | 0.0 | 1.0 | 96962052/rs74973995 | - | 0.2% | 32.6 | 1 × 10−8 | * |
12 | CREBL2 | 12796872/rs4555 | 892 | 55.8% | 54.9% | 57.1% | −0.4 | 0.3 | 0.3 | 0.3 | −0.1 | 0.1 | T | 0.9 | 0.4 | 12796872/rs4555 | A | - | - | 0.05 | ♦ |
12 | CPM | 69309377/rs1144961 | 892 | 25.4% | 24.8% | 25.8% | −0.3 | 0.4 | −0.3 | 0.4 | 0.1 | 0.1 | A | −0.7 | 0.5 | 69309377/rs1144961 | G | - | - | 0.05 | ♦ |
14 | SLC24A4 | 92960148/rs4900131 | 892 | 14.9% | 13.1% | 17.9% | −0.6 | 0.4 | −0.4 | 0.5 | 0.0 | 0.1 | T | −1.7 | 0.1 | 92959857/rs77441273 | - | 0.2% | 23.6 | 4 × 10−10 | * |
16 | ADCY9 | 4192082/rs7201216 | 892 | 4.6% | 3.2% | 3.2% | 0.5 | 0.7 | 0.9 | 1.0 | −0.1 | 0.3 | A | −0.9 | 0.4 | 4191522/rs144315541 | - | 0.7% | −6.7 | 4 × 10−4 | * |
20 | NCOA3 | 46282645/rs72646209 | 766 | 0.5% | 1.7% | 0.4% | −3.9 | 2.1 | −2.9 | 1.9 | NA | NA | A | −2.4 | 2 × 10−2 | 46282708/rs115501901 | - | 0.2% | 31.5 | 4 × 10−8 | * |