Table 2.
Statistical significance of clinical findings for severe patients who increased in oxygen requirement, and non-severe patients.
| severe n (%), N = 40 |
non-severe n (%), N = 167 |
P-value | |
|---|---|---|---|
| Nationality | 0.53 | ||
| Asia | 35 (88) | 151 (90) | |
| Europe | 0 (0) | 4 (2) | |
| North or South America | 3 (8) | 9 (5) | |
| Oceania | 2 (5) | 3 (2) | |
| Current or ex-smoker | 14 (35) | 52 (31) | 0.11 |
| Comorbidities | |||
| Cardiovascular disease | 5 (13) | 7 (4) | 0.04 |
| Diabetes | 3 (8) | 9 (5) | 0.61 |
| Hypertension | 9 (23) | 24 (14) | 0.88 |
| Chronic respiratory disorder | 5 (13) | 15 (9) | 0.5 |
| Malignancy | 1 (3) | 5 (3) | 0.87 |
| Age (≧65 years old) | 10 (25) | 70 (42) | <0.05 |
| Laboratory abnormalities | |||
| Blood pressure (sBP< 90 mmHg or dBP< 60 mmHg) | 2 (5) | 7 (4) | 0.82 |
| Respiratory rate (≧30/min) | 4 (10) | 2 (1) | <0.01 |
| BUN (>19 mg/dL) | 8 (20) | 21 (13) | 0.22 |
| Albumin (<3.5 g/dL) | 9 (23) | 12 (7) | <0.01 |
| LDH (>230 u/L) | 27 (68) | 52 (31) | <0.001 |
| Lymphopenia (<800/μL) | 14 (35) | 33 (19.7) | 0.04 |
| elevation of CRP (≧10 mg/dL) | 11 (28) | 5 (3) | <0.001 |
| elevation of liver enzyme (AST> 40 IU/L and/or ALT> 40 IU/L) | 19 (48) | 43 (26) | 0.001 |
| elevation of D-dimer (>1 mg/dL) (N = 92) | N = 39 15 (39) |
N = 53 13 (25) |
<0.001 |
| CT [score median (25%, 75%)] | 9 (4.5, 13) | 3 (2, 7) | <0.001 |
sBP = systolic blood pressure; dBP = diastolic blood pressure; BUN = blood urea nitrogen; LDH = lactate dehydrogenase; CRP= C-reactive protein; AST = aspartate aminotransferase; ALT = alanine aminotransferase.