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. 2020 Dec 9;126(3):590–598. doi: 10.1016/j.bja.2020.12.010

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 1 — Decreased fibrinolytic response in critically ill COVID-19 patients. The numbers below the box plots depict median (25th to 75th percentile) and estimated median differences with corresponding 95% confidence intervals (CIs) and P-value. (a) Prolonged lysis time (LT) in the TPA test assay in critically ill COVID-19 patients as compared with healthy persons. Fibrinogen levels (b), platelet counts (d), and levels of C-reactive protein (e) were significantly elevated in patients with decreased fibrinolytic response, whereas D-dimers did not differ between patients with and without impaired fibrinolysis (c).