Table 1.
ClotPro analysis in healthy individuals compared with critically ill COVID-19 patients.
| Total (n=80) | Healthy (n=60) | COVID-19 (n=20) | Estimate with 95% CIa | P-valueb | Not known | |
|---|---|---|---|---|---|---|
| TPA test | ||||||
| CT (s) | 43 (37–51) | 42 (36–46) | 50 (42–90) | –12 (–38 to –3) | <0.01 | 0/0 |
| LT (s) | 238 (198–324) | 210 (186–261) | 508 (365–827) | –265 (–358 to –186) | <0.01 | 0/0 |
| MCF (mm) | 34 (29–41) | 32 (28–36) | 55 (38.75–64) | –21 (–27 to –13) | <0.01 | 0/0 |
| ML (%) | 95 (94–96) | 95 (94–96) | 97 (95–98) | –2 (–2 to –1) | <0.01 | 0/0 |
| EX test | ||||||
| CT (s) | 49 (45–55) | 48.5 (45–54) | 51.5 (47–76) | –5 (–16 to 1) | 0.08 | 0/0 |
| A5 (mm) | 49.5 (46–55) | 48 (44–52) | 58 (50–61) | –9 (–12 to –5) | <0.01 | 0/0 |
| A10 (mm) | 57 (54–62) | 56 (53–59) | 65.5 (58–68) | –8 (–11 to –4) | <0.01 | 0/0 |
| A20 (mm) | 61 (58–65) | 60 (58–63) | 68 (62–70) | –6.39 (–9 to –4) | <0.01 | 0/0 |
| MCF (mm | 62 (59–65) | 61 (58–64) | 68.5 (63–71) | –6 (–9 to –3) | <0.01 | 0/0 |
| ML (%) | 5 (3–8) | 6 (4–8) | 3 (2–7) | 2 (1–4) | <0.01 | 0/1 |
| IN test | ||||||
| CT (s) | 162 (154–176) | 159 (153–166) | 188 (168–215) | –30 (–47 to –17) | <0.01 | 0/0 |
| A5 (mm) | 45 (42–48) | 44 (41–47) | 52 (44–57) | –8 (–11 to –4) | <0.01 | 0/0 |
| A10 (mm) | 54 (50–57) | 53 (50–55) | 60 (53–64) | –7 (–10 to –4) | <0.01 | 0/0 |
| A20 (mm) | 59 (55–61) | 58 (55–60) | 64.5 (58–68) | –6 (–9 to –3) | <0.01 | 0/0 |
| MCF (mm) | 59 (56–62) | 59 (56–61) | 64 (59–69) | –5 (–8 to –2) | <0.01 | 0/0 |
| ML (%) | 5 (3–7) | 5 (3.5–7) | 4 (3–8) | 1 (–1 to 2) | 0.50 | 1/3 |
| FIB test | ||||||
| CT (s) | 68 (62–77) | 68 (63–75) | 72 (53–108) | –4 (–25 to 9) | 0.57 | 0/0 |
| A5 (mm) | 14 (10–20) | 12 (9–15) | 29 (23–32) | –16 (–19 to –14) | <0.01 | 0/0 |
| A10 (mm) | 16 (11–22) | 14 (10–17) | 31 (25–35) | –17 (–20 to –14) | <0.01 | 0/0 |
| A20 (mm) | 17 (12–24) | 15 (12–18) | 33 (27–37) | –17 (–21 to –14) | <0.01 | 0/0 |
| MCF (mm) | 19 (14–26) | 17 (13–20) | 34 (28–39) | –17 (–21 to –14) | <0.01 | 0/0 |
Continuous data are presented as medians (25th to 75th percentile).
A5, amplitude after 5 min; A10, amplitude after 10 min; A20, amplitude after 20 min; CI, confidence interval; CT, clotting time; LT, lysis time; MCF, maximal clot firmness; ML, maximum lysis.
a
Odds ratios for binary variables and estimated median difference for continuous variables (CI).
b
Assessed with Fisher's exact test for categorical variables and the Wilcoxon rank sum test for continuous variables.