Table 2.
Baseline characteristics of COVID-19 patients.
| Total (n=20) | TPA LT ≤393 s (n=6) | TPA LT >393 s (n=14) | Estimate with 95% CIa | P-valueb | Not known | |
|---|---|---|---|---|---|---|
| Age (yr) | 61.5 (56.25–68) | 66 (61–70.25) | 61 (54.75–65.25) | 6 (–4 to 15) | 0.27 | 0/0 |
| Female sex | 6/20 (30%) | 2/6 (33.3%) | 4/14 (28.6%) | 0.81 (0.07–12.38) | 1 | 0/0 |
| Height (cm) | 174 (170–176) | 166 (163–169) | 174 (170–177) | –10 (–25 to 4) | 0.19 | 4/5 |
| Weight (kg) | 82 (74.2–97) | 82 (80–98) | 84 (73.9–95) | 4.5 (–18 to 23) | 0.71 | 1/4 |
| BMI (kg m−2) | 28.8 (24.3–31.0) | 28.3 (25.9–30.7) | 28.8 (25.6–30.8) | 2.0 (–9.2 to 13.3) | 0.71 | 4/6 |
| History of thromboembolic events | 2/20 (10%) | 0/6 (0%) | 2/14 (14.3%) | Inf (0.08 to Inf) | 1 | 0/0 |
| Medical history | ||||||
| Cardiovascular | 8/20 (40%) | 4/6 (66.7%) | 4/14 (28.6%) | 0.22 (0.01–2.24) | 0.16 | 0/0 |
| Central nervous system | 4/20 (20%) | 1/6 (16.7%) | 3/14 (21.4%) | 1.34 (0.08–85.67) | 1 | 0/0 |
| Coagulation | 2/20 (10%) | 0/6 (0%) | 2/14 (14.3%) | Inf (0.08 to Inf) | 1 | 0/0 |
| Diabetes mellitus | 5/20 (25%) | 0/6 (0%) | 5/14 (35.7%) | Inf (0.42 to Inf) | 0.26 | 0/0 |
| Gastrointestinal | 3/20 (15%) | 0/6 (0%) | 3/14 (21.4%) | Inf (0.17 to Inf) | 0.52 | 0/0 |
| Haematologic | 1/20 (5%) | 0/6 (0%) | 1/14 (7.1%) | Inf (0.01 to Inf) | 1 | 0/0 |
| Hepatologic | 3/20 (15%) | 2/6 (33.3%) | 1/14 (7.1%) | 0.17 (0–4.11) | 0.20 | 0/0 |
| Hypertension | 10/20 (50%) | 2/6 (33.3%) | 8/14 (57.1%) | 2.54 (0.26–37.18) | 0.63 | 0/0 |
| Immune | 1/20 (5%) | 1/6 (16.7%) | 0/14 (0%) | 0 (0–16.71) | 0.3 | 0/0 |
| Scores on ICU admission | ||||||
| SAPS 3 (points) | 56 (53–64) | 56 (55–66) | 55 (53–61.5) | 3 (–6 to 14) | 0.38 | 1/0 |
| SOFA Respiratory system (points) | 3 (3–4) | 3 (3–3) | 3 (3–4) | 0 (–1 to 1) | 0.79 | 0/0 |
| SOFA Respiratory system >2 | 17/20 (85%) | 6/6 (100%) | 11/14 (78.6%) | 0 (0–5.81) | 0.52 | 0/0 |
| SOFA Coagulation (points) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.26 | 0/0 |
| SOFA Liver (points) | 0 (0–0) | 0 (0–0.75) | 0 (0–0) | 0 (0–1) | 0.44 | 0/0 |
| SOFA Cardiovascular system (points) | 3 (0–3.25) | 0 (0–2.25) | 3 (0.75–3.75) | –1 (–3 to 0) | 0.20 | 0/0 |
| SOFA Cardiovascular system >2 | 12/20 (60%) | 2/6 (33.3%) | 10/14 (71.4%) | 4.57 (0.45–70.73) | 0.16 | 0/0 |
| SOFA Nervous system (points) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.59 | 0/0 |
| SOFA Renal (points) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (–1 to 0) | 0.36 | 0/0 |
| SOFA (points) | 6.5 (3–8.25) | 3.5 (3–6.25) | 7 (3.5–8.75) | –2 (–5 to 1) | 0.30 | 0/0 |
Binary data are presented as no./total no. (%), continuous data as medians (25th to 75th percentile).
CI, confidence interval; TPA LT, lysis time in TPA test; SAPS 3, Simplified Acute Physiology Score 3; SOFA, Sequential Organ Failure Assessment.
a
Odds ratios for binary variables and estimated median difference for continuous variables (CI).
b
Assessed with Fisher's exact test for categorical variables and the Wilcoxon rank sum test for continuous variables.