Table 3.
ClotPro analysis of critically ill COVID-19 patients with decreased fibrinolytic response compared with critically ill COVID-19 patients with normal fibrinolytic response.
| Total (n=20) | TPA LT ≤393 s (n=6) | TPA LT >393 s (n=14) | Estimate with 95% CIa | P-valueb | Not known | |
|---|---|---|---|---|---|---|
| TPA test | ||||||
| CT (s) | 49.5 (41.5–90.2) | 73.5 (46.5–109.5) | 47.5 (40.5–84.25) | 12 (–19 to 66) | 0.27 | 0/0 |
| LT (s) | 508 (364.75–826.75) | 321.5 (278.75–347) | 573 (503–982) | –296.5 (–688 to –160) | <0.01 | 0/0 |
| MCF (mm) | 55 (38.75–64) | 34 (27.5–43.5) | 62 (55–64.75) | –22.98 (–36 to –10) | <0.01 | 0/0 |
| ML (%) | 97 (95–98) | 95.5 (95–96.75) | 97 (96.25–98) | –1 (–3 to 0) | <0.01 | 0/0 |
| EX test | ||||||
| CT (s) | 51.5 (46.75–76.25) | 72 (46.25–106) | 51.5 (47–65.5) | 13.49 (–15 to 62) | 0.59 | 0/0 |
| A5 (mm) | 58 (50–61) | 49 (47.25–52.25) | 59.5 (57.25–64) | –10 (–15 to –3) | 0.01 | 0/0 |
| A10 (mm) | 65.5 (58–67.5) | 56.5 (55–59.5) | 66 (64.5–69) | –9 (–14 to –3) | <0.01 | 0/0 |
| A20 (mm) | 67.5 (62–70.25) | 60 (57.25–62.75) | 69.5 (67.25–71.75) | –8.9 (–13 to –3) | <0.01 | 0/0 |
| MCF (mm) | 68.5 (62.75–71.25) | 60 (57.25–62.75) | 70.5 (68.25–72) | –9 (–14 to –4) | <0.01 | 0/0 |
| ML (%) | 3 (2–7) | 7.5 (4.75–8.75) | 2 (1–3) | 4.6 (1–7) | <0.01 | 0/1 |
| IN test | ||||||
| CT (s) | 188 (167.75–214.75) | 203 (183.75–250) | 180 (164–208.25) | 23 (–18 to 71) | 0.11 | 0/0 |
| A5 (mm) | 52.5 (44–56.75) | 44 (41.75–45.5) | 54.5 (51.5–59) | –10.75 (–15 to –3) | 0.01 | 0/0 |
| A10 (mm) | 60.5 (53–64.5) | 53 (50–54.5) | 62 (60.25–66) | –9 (–14 to –3) | 0.01 | 0/0 |
| A20 (mm) | 64.5 (58–68.25) | 57.5 (54–58.75) | 66.5 (64.25–69) | –9 (–13 to –4) | <0.01 | 0/0 |
| MCF (mm) | 64.5 (59–69) | 58 (54–59) | 66.5 (64.25–69) | –9.99 (–14 to –3) | <0.01 | 0/0 |
| ML (%) | 4 (3–8) | 7.5 (4.75–9.5) | 3 (2–4) | 4 (0–7) | 0.04 | 0/3 |
| FIB test | ||||||
| CT (s) | 72 (53–108) | 94 (64–119) | 66 (52–104) | 15 (–18 to 61) | 0.28 | 0/0 |
| A5 (mm) | 29 (23–32) | 22 (18–25) | 32 (28–34) | –10 (–15 to –3) | <0.01 | 0/0 |
| A10 (mm) | 31 (25–35) | 24 (20–27.25) | 34 (31–36.5) | –10 (–16 to –4) | <0.01 | 0/0 |
| A20 (mm) | 33 (27–37) | 25 (22–28) | 36 (32–38) | –11 (–16 to –4) | <0.01 | 0/0 |
| MCF (mm) | 34 (28–39) | 26 (24–30) | 38 (34–40) | –11 (–17 to –4) | <0.01 | 0/0 |
Continuous data as medians (25th to 75th percentile).
A5, amplitude after 5 min; A10, amplitude after 10 min; A20, amplitude after 20 min; CI, confidence interval; CT, clotting time; LT, lysis time; MCF, maximal clot firmness; ML, maximum lysis; TPA LT, lysis time in TPA test.
a
Odds ratios for binary variables and estimated median difference for continuous variables (CI).
b
Assessed with Fisher's exact test for categorical variables and the Wilcoxon rank sum test for continuous variables.