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PCs (PSCK) and trypsin like enzymes that can cleave the S1/S2 boundary and activate the virus. A more flexible tetra peptide query set derived from cleavage sites of Serine proteases deposited in MEROPS was used to scan the SARS-CoV-2 spike protein. The logic was based on our program PNSAS created to identify proteolytic sites on natural substrates. The sequence matched sites, accessible on the surface of the S1 domain are indicated.
