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. 2021 Jan 13;25:100907. doi: 10.1016/j.bbrep.2021.100907

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 8 — The polybasic insert in different isolates of feline corona viruses. The AJO27013.1, AJO26993.1, AJO27003.1 are from spike proteins of SARS isolated from healthy cats. AJO27023.1, AJO26973.1, and AJO26983.1 are from infected cats and belong to the FIPV isolates associated with systemic infection and lethality. RRARR↓S at the S1/S2 boundary found in isolates from healthy cats is one of the well-optimized furin cleavage sequences. This is mutated to a sequence that cannot be cleaved by Furin or has been lost in the FIPV strains.