Table 1.

Comparison of residues in the RBD region of the feline CoV spike protein with the interface residues of the SARS-CoV-2-ACE2 receptor complex. Individual pairwise alignment of each of the six isolates with SARS-CoV-2 spike protein was performed using the Needleman-Wunsch algorithm. All six isolates have the same RBD residues. Residues that form the interface of SARS-CoV-2 RBD with the ACE2 receptor as reported in PDB 6MOJ (Fig. 6), were compared with all six isolates and the FIPV isolate reported in Uniprot. The conserved residues are highlighted in yellow., the synonymous mutation Asn to Gln in green and those conserved only with P10033 FIPV in grey.