Table 2.

Outcomes.

	Ozonated Autohemotherapy (n = 9)	Usual Clinical Care (n = 9)	p-value
Primary outcome
Time to clinical improvement, median [IQR], days	7 [6–10]	28 [8–31]	0.04
Secondary outcomes
Clinical improvement at day 7, n (%)	4 (44%)	2 (22%)	0.31
Clinical improvement at day 14, n (%)	8 (89%)	3 (33%)	0.01
Clinical improvement at day 28, n (%)	8 (89%)	5 (56%)	0.29
6-point ordinal scale day 7, median [IQR]	2 [1–2]	2 [1–4]	0.45
6-point ordinal scale day 14, median [IQR]	1 [1]	1 [1–4]	0.29
6-point ordinal scale day 28, median [IQR]	1 [1]	1 [1–2]	0.30
Time to Temperature <37C, median [IQR], days	1 [1–1.5]	4 [2–5]	0.10
Time to PCR COVID-19 negative, mean (SD), days	13.1 (5.7)	21.4 (7.4)	0.05
Time to a 2-fold decreased C-reactive protein, median [IQR], days	3.5 [3–28]	13 [8–25]	0.008
Time to a 2-fold decreased D-dimer, median [IQR], days	4 [1–10]	19.5 [10–28]	0.009
Time to a 2-fold decreased ferritin, median [IQR], days	8 [5–10]	15 [10–25]	0.016
Time to a 2-fold decreased Lactate Dehydrogenase, median [IQR], days	9 [7–9]	25 [12–26]	0.01
Ventilator-free days at day 28, median [IQR], days	28 [28]	28 [0–28]	0.14
Intubation required, n (%)	0 (0%)	2 (22.%)	0.47
ICU-length of stay, median [IQR], days	0 [0–0]	0 [0–0]	0.24
Hospital-length of stay, median [IQR], days	8 [7–12]	28 [8–31]	0.09
In-hospital mortality, n (%)	1 (11%)	2 (22%)	1
28-day hospital mortality, n (%)	1 (11%)	2 (22%)	1

ICU: Intensive Care Unit. IQR: Interquartile range. SD: Standard difference. SOFA: Sequential Organ Failure Assessment.