Table 1.
Clinical progress of the patient.
| At admission | Day 1 | Day 3 | Day 4 | Day 8 | Day 11 | Day 14 | |
|---|---|---|---|---|---|---|---|
| Fever (°C) | 38.7 | 37.8 | 38.2 | 38.4 | 38.8 | 36.8 | 36.3 |
| Respiratory rate (per min) | 36 | 26 | 24 | 34 | 32 | 14 | 12 |
| Ventilation support | Oxygen mask | OMRB | OMRB | Helmet mask | Helmet mask | Oxygen mask | Air room |
| sPO2 (%) | 82 | 92 | 76 | 96 | 98 | 98 | 96 |
| PO2 (mmHg) | 68 | 43 | 72 | 84 | 82 | 78 | |
| PCO2 (mmHg) | 42 | 49 | 38 | 36 | 38 | 40 | |
| PO2/FiO2 | 204 | 132 | 256 | 288 | 310 | 380 | |
| Ph | 7.32 | 7.25 | 7.30 | 7.36 | 7.34 | 7.42 | |
| Bicarbonate (mmoL.L−1) (22–26) |
24 | 26 | 18 | 30 | 22 | 22 | |
| Laktat (mmoL.L−1) (0.5–1) |
1,1 | 2,1 | 2,3 | 2,2 | 1,6 | 0.9 | |
| Hemoglobin (g.L−1) (12–17) | 12 | 11 | 9 | 8 | 8 | 10 | 11 |
| White-cell count (per mm3) (400−10,000) |
2600 | 2500 | 2400 | 2200 | 3300 | 3800 | 4200 |
| Platelet count (per mm3) (100,000–400,000) |
192,000 | 158,000 | 102,000 | 72,000 | 88,000 | 186,000 | 224,000 |
| BUN (mg.dL−1) (8–20) |
24 | 26 | 28 | 30 | 25 | 20 | 16 |
| Creatinine (mmoL.L−1) (0.51–0.95) |
092 | 093 | 1,1 | 1,4 | 1,2 | 096 | 084 |
| ALT (U.L−1) (0–35) |
21 | 23 | 39 | 78 | 55 | 49 | 27 |
| AST (U.L−1) (0–35) |
24 | 52 | 62 | 83 | 64 | 53 | 28 |
| Fibrinogen (mg.dL−1) (200–400) |
320 | 280 | 160 | 120 | 140 | 220 | 340 |
| Ferritin (ng. mL−1) (11–306) |
1400 | 2560 | 3400 | 4200 | 5800 | 1800 | 1200 |
| Triglycerides (mg.dL−1) (<130) |
123 | 138 | 264 | 316 | 320 | 126 | 122 |
| INR (0.8–1.2) |
1,2 | 1,3 | 1,5 | 1,7 | 1,6 | 1,5 | 1,3 |
| IL-6 (pg. mL−1) (0–6.4) |
14 | 34 | 178 | 122 | 84 | 16 | |
| CRP (mg.dL−1) (0–5) |
78 | 104 | 136 | 265 | 138 | 82 | 11 |
| Troponin (ng.L−1) (0–11.6) |
4 | 7 | 8 | 10 | 9 | 8 | 4 |
| D-dimer (mg.L−1) (0–500) |
307 | 871 | 1839 | 1980 | 1873 | 1271 | 420 |
| H-score | 195 | 73 | |||||
| PCR | Positive | Positive | Negative | ||||
| Drugs | PAR 3 × 1 g | PAR 3 × 1 g | PAR 3 × 1 g | FAVI 2 × 1600 mg, then 2 × 600 mg | TCZ 2 × 400 mg IV | ENO 2 × 40 mg | ENO 2 × 40 mg |
| AZI 500 mg | AZI 4 × 250 mg | AZI 4 × 250 mg | |||||
| OSE 2 × 75 mg | OSE 2 × 75 mg | OSE 2 × 75 mg | ENO 2 × 40 mg | ENO 2 × 40 mg | |||
| HCLQ 2 × 400 mg | HCLQ 2 × 200 mg | HCLQ 2 × 200 mg | |||||
| ENO 2 × 40 mg | ENO 2 × 40 mg |
OMRB, Oxygen Mask with Reservoir Bag; PAR, Paracetamol; AZL, Azithromycin; OSE, Oseltamivir; HCLQ, Hydroxychloroquine; FAVI, Favipiravir; TCZ, Tocilizumab; ENO, Enoxaparin; iv, intravenous. (-) Normal range of a parameter.