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. 2020 Oct 29;80(6):1055–1066.e6. doi: 10.1016/j.molcel.2020.10.034

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Nsp1 Prevents Physiological Conformation of the 48S PIC

(A) Overall structure of the Nsp1-40S-CrPV IRES complex. Nsp1 (green) and IRES (yellow) are presented in surface. The ribosome proteins (slate) and rRNA (orange) are shown in cartoon. The right insets display the conformation change in the Nsp1-binding region (cartoon representation) with or without the IRES.

(B) The previously reported model of CrPV IRES (PDB: 5IT9; orange cartoon) fitted to 40S ribosome in the present of Nsp1 (green cartoon). 40S ribosome (slate) and the currently observed IRES (yellow) are presented in surface.

(C) C-Nsp1 restricts the 40S ribosome head rotation. Superposition of the Nsp1-40S, Nsp1-40S-CrPV IRES, and IRES-40S (PDB: 5IT9) complexes is shown is cartoon. Zoomed view displays the head rotations represented by selected rRNA regions. C-Nsp1 (green) is displayed in surface.

See also Figure S6.