Table 1.
The effects of recombinant tissue plasminogen activator treatment on echocardiographic parameters, respiratory mechanics, blood parameters, and ventilation status.
| Echocardiography | Before | After |
|---|---|---|
| SPAP, mmHg | 52 | 40 |
| RV basal diameter, mm | 37 | 36 |
| RV midlevel diameter, mm | 35 | 33 |
| RV end-diastoliс area, cm2 | 22 | 20 |
| RA end-systolic area, cm2 | 17 | 16.4 |
| TAPSE, mm | 18 | 20 |
| Respiratory mechanics | ||
| Rrs, cmH2O/L/s | 16 | 16 |
| Static respiratory system compliance, mL/cmH2O | 50 | 58 |
| R/I ratio | 0.38 | 0.39 |
| Driving pressure, cmH2O | 13 | 12 |
| Blood gas analysis | ||
| PaO2/FiO2, mmHg | 116 | 170 |
| PaCO2, mmHg | 70 | 39 |
| pH | 7.38 | 7.43 |
| HCO3−, mEq/L | 31.6 | 27.6 |
| Ventilation status | ||
| Alveolar dead space, mL | 204.3 | 53.8 |
| Ventilatory ratio | 3.73 | 2.05 |
| Blood analysis | ||
| D-dimers, mg/L | 53.6 | 56.3 |
| CRP, mg/L | 68 | 19 |
| Ferritin, ng/mL | 2142 | 1254 |
| ALT, U/L | 133 | 81 |
| AST, U/L | 127 | 60 |
| LDH, U/L | 2540 | 1643 |
Abbreviations: SPAP = systolic pulmonary arterial pressure, RA = right atrium, RV = right ventricle, TAPSE = tricuspid annular plane systolic excursion, Rrs = respiratory system resistance, R/I = recruitment-to-inflation, PaO2 = partial pressure of oxygen, FiO2 = fraction of inspired oxygen, PaCO2 = partial pressure of carbon dioxide, CRP = C-reactive protein, ALT = alanine transaminase, AST = aspartate transaminase, LDH = lactate dehydrogenase, ventilatory ratio = minute ventilation (mL/min) × PaCO2 (mmHg)/(predicted body weight × 100 × 37.5).