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In vivo protection against ETEC challenge. Groups of 8 mice were inoculated with ~1x109 Escherichia coli (H10407) mixed with 68–61 SIgA2 produced in N. benthamiana WT, ΔXF SIgA2 or CHO cells, or PBS only. In addition, a group of 12 mice were untreated and not infected. The percentage of mice developing diarrhea within 7 d is shown. Diarrhea was defined as unformed or watery stools occurring on any day of daily observations in each mouse
