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. 2020 Jul 3;758:144944. doi: 10.1016/j.gene.2020.144944

Table 1.

ACE1 II genotype frequency and the number of COVID-19 cases and deaths among European, Middle Eastern, South Asian and East Asian countries.

Country Study authors Year of
No. of
ACE1 II
#COVID-19 cases case/pop
deaths death/pop
publication subjects frequency (%) (n/million) (n/million)
Sweden Kurland et al. 2001 59 27 33,188 3307 3,992 398
Denmark Bladbjerg et al. 1999 199 23 11,487 1990 561 97
United Kingdom Kehoe et al. 1999 386 23 258,504 3828 36,757 544
United Kingdom Steeds et al. 2001 507 22 258,504 3828 36,757 544
United Kingdom Narain et al. 2000 342 18 258,504 3828 36,757 544
Netherlands Hosoi et al. 1996 61 20 45,265 2648 5,830 341
Hungary Barkai et al. 2005 120 27 3,741 386 482 50
Belgium Gu et al. 1994 109 19 56,810 4923 9,237 800
Germany Ebert et al. 2005 145 23 179,986 2155 8,261 99
Germany Filler et al. 2001 200 18 179,986 2155 8,261 99
France Blanche et al. 2001 560 18 182,036 2795 28,218 433
France Girerd et al. 1998 340 17 182,036 2795 28,218 433
Spain Alvarez et al. 1999 400 15 235,290 5034 28,678 614
Spain Coll et al. 2003 133 15 235,290 5034 28,678 614
Italy Di Pasquale et al. 2005 684 18 229,327 3787 32,735 541
Italy Panza et al. 2002 252 13 229,327 3787 32,735 541
Portugal Freitas et al. 2008 510 16 36,690 3569 1,517 148
Switzerland Walder et al. 1998 199 25 31,117 3631 1,938 226
Poland Borzyszkowska et al. 2012 632 29 29,392 774 1,247 33
Slovakia Siváková et al. 2009 209 25 1,548 284 28 5
Iran Nikzamiret et al. 2008 51 16 187,427 2291 8,837 108
Israel Frishberg et al. 1998 216 10 19,121 2152 302 34
Turkey Tanriverdi et al. 2005 102 23 150,388 1834 4,182 51
Turkey Serdaroglu et al. 2005 287 23 150,388 1834 4,182 51
Turkey Bedir et al. 1999 143 23 150,388 1834 4,182 51
Lebanon Saab et al. 2007 570 7 1089 159 27 4
Kuwait Al-Eisa et al. 2001 48 2 19,858 4800 145 35
United Arab Emirates Saeed et al. 2005 130 6 27,198 2824 231 24
India Patil et al. 2005 300 26 124,476 92 4,059 3
China Thomas et al. 2001 119 33 84,084 59 4,638 3
China Ohishi et al. 1994 175 37 84,084 59 4,638 3
China Young et al. 1998 183 39 84,084 59 4,638 3
China Iwai et al. 1994 122 41 84,084 59 4,638 3
China Yan et al. 2005 352 41 84,084 59 4,638 3
Korea, South Ryu et al. 2002 167 34 11,190 218 266 5
Korea, South Um et al. 2003 613 37 11,190 218 266 5
Taiwan Lee et al. 2002 750 47 441 19 7 0
Japan Katoh et al. 2005 270 41 16,536 130 808 6
Japan Odawara et al. 1997 248 42 16,536 130 808 6
Japan Mannami et al. 2001 3657 43 16,536 130 808 6
Japan Maguchi et al. 1996 84 48 16,536 130 808 6
Japan Ishigami et al. 1995 87 51 16,536 130 808 6
Japan 1000G JPT 104 33 16,536 130 808 6
Korea, South KPGP 88 41 11,190 218 266 5

Information of ACE1 II genotype frequencies in each country were found in the references listed in the left half of the table, while those on the number of COVID-19 cases and deaths were collected from the Center for Systems Science and Engineering at Johns Hopkins University (https://coronavirus.jhu.edu/map.html) (as of May 23, 2020) and listed in the right half of the table, respectively.