Figure 4.

Network overlay of interactome CRISPR screening

(A) Interactome network organized by virus bait protein from largest to smallest number of putative interactors. Enriched or depleted hits are highlighted in labeled purple or orange filled circles, respectively. Border colors denote SARS-CoV-2 hits that are shared with any other coronavirus screen (green), hits exclusive to SARS-CoV2 (red), or hits exclusive to other HCoVs (gray) with size of node scaled with significance.

(B) Barplot of nodes per viral protein with all SARS-CoV-2 shared and exclusive hits indicated in blue. Hits for other CoVs are shown in dark gray. Percentage of genes that scored as a hit in any screen are indicated for all genes with greater than 10 edges. ^∗p < 0.05 based on hypergeometric test