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. 2020 Dec 16;29(2):267–280.e5. doi: 10.1016/j.chom.2020.12.009

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© 2020 Elsevier Inc.

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Pathway focused views of high confidence CRISPR hits

(A) Heatmap of Z scores for the union of positively enriched coronavirus host factors across experimental replicates in all infection conditions. Functionally related genes are highlighted.

(B) Distribution of gene essentiality (beta) scores for the pathways highlighted in (A).

(C) SCAP/SREBP pathway regulating cholesterol homeostasis. Diagram created with BioRender.com. Modified from Shimano and Sato (2017).

(D) Rab GTPases and intracellular vesicle trafficking. Diagram created with BioRender.com. Modified from Stenmark (2009).

(E) Biosynthesis of GPI-anchored proteins. Diagram created with BioRender.com. Modified from Maeda et al. (2017).

See also Figure S4.