Table 1.
Baseline characteristics of the CHC patients
| Total, n = 842 | SVR (+), n = 427 | SVR (-), n = 92 | p Values | |
|---|---|---|---|---|
| Male, n (%) # | 449 (53.3) | 248 (58.1) | 47 (51.1) | 0.231 |
| Age (year) | 55.30±12.50 | 53.83±11.48 | 56±10.92 | 0.086 |
| BMI (kg/m2) | 24.85±3.875 | 24.84±3.572 | 25.54±4.112 | 0.126 |
| HCV RNA (Log10 IU/ml) | 4.191±7.338 | 4.628±8.505 | 6.220±6.889 | <0.001 |
| HCV genotype, n (%)# | ||||
| Genotype 1 | 466 (55.3) | 204 (47.8) | 74 (80.4) | <0.001 |
| Genotype 2 | 314 (37.3) | 196 (46) | 14 (15.2) | <0.001 |
| Others | 62 (7.3) | 27 (6.3) | 4 (4.3) | 0.368 |
| Uric acid (mg/dL) | 5.91±1.55 | 5.97±1.55 | 5.81±1.50 | 0.404 |
| HOMA-IR | 3.18±5.14 | 2.91±4.41 | 4.34±5.41 | 0.028 |
| C-peptide (ng/mL) | 2.56±1.92 | 2.46±1.84 | 3.35±3.06 | 0.016 |
| Liver cirrhosis, n (%) # | 181 (21.5) | 77 (18.1) | 36 (39.1) | <0.001 |
| ALT (U/L) | 92.21±98.34 | 100.8±103.8 | 85.31±78.02 | 0.188 |
| Platelets count (103/µL) | 178.7±66.27 | 180.9±58.19 | 154.1±57.68 | <0.001 |
| TC (mg/dL) | 173.7±34.32 | 174.3±32.21 | 173.2±30.24 | 0.87 |
| TGs (mg/dL) | 109.0±59.73 | 110.4±60.86 | 100.2±57.90 | 0.433 |
| HDL-C (mg/dL) | 47.71±13.77 | 47.82±13.89 | 47.83±14.53 | 0.993 |
| HS-CRP (mg/dL) | 1.93±3.90 | 1.71±3.56 | 1.75±3.14 | 0.913 |
| eNAMPT (ng/mL) | 5.93±4.17 | 5.95±4.06 | 5.50±3.24 | 0.382 |
| eGFR (ml/min) | 100.5±32.5 | 100.6±30.6 | 99.5±33.9 | 0.779 |
| rs12979860, CC genotype, n (%) # | 726 (86.2) | 380 (89.41) | 65 (70.7) | <0.001 |
| rs61330082, TT genotype, n (%) # | 168 (19.9) | 96 (22.5) | 21 (23.0) | 0.477 |
| rs7789066, AA genotype, n (%) # | 841 (99.9) | 426 (99.8) | 92 (100) | 0.824 |
| rs10953502, TT genotype, n (%) # | 692 (82.2) | 349 (80.5) | 75 (81.5) | 0.889 |
| rs2302559, CC genotype, n (%) # | 638 (75.8) | 330 (77.3) | 64 (70.0) | 0.314 |
| rs10487818, AA genotype, n (%) # | 842 (100) | 427 (100) | 92 (100) | NA |
| rs2058539, AA genotype, n (%) # | 653 (77.6) | 336 (78.7) | 71 (77.4) | 0.654 |
| rs1319501, TT genotype, n (%) # | 842 (100) | 427 (100) | 92 (100) | NA |
| rs9770242, AA genotype, n (%) # | 842 (100) | 427 (100) | 92 (100) | NA |
CHC: chronic hepatitis C virus infection; #: chi-squared test; SVR: sustained virological response; BMI: body mass index; Log: logarithmic; HOMA-IR: homeostasis model assessment-estimated insulin resistance; ALT: alanine aminotransferase; TC: total cholesterol; TGs: triglycerides; HDL-C: high-density lipoprotein-cholesterol; HS-CRP: high sensitive C-reactive protein; eGFR: estimated glomerular filtration rate; eNAMPT: extracellular nicotinamide phosphoribosyltransferase; NA: not assessable due to no polymorphism.