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PDCoV N protein degrade the poIRF7 via ubiquitin-proteasomal pathway. PDCoV infect and release its genome and N protein into the porcine cytoplasm. The N protein could bind to the C-terminal rigion (262-487aa) of poIRF7. Then it promotes the K6, K11 and K29-linked polyubiquitination of poIRF7 at K359 site to dregrade it via 26S proteasome, which results in suppressing the type I IFN production.
