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HMGA2 mediates the stability of YAP protein in TNBC
(a,c): MDA-MB-231 and SUM149 transfected cells were treated with CHX (20μM) for 0 h, 1 h, 2 h, 4 h, 6 h, 8 h.The knockdown of HMGA2 led to the increased turnover of YAP protein compared with the control cells, implying that HMGA2 regulates YAP stability. (b,d): The graphs panels were shown. (*P<.05, **P<.01, ***P<.001) E: Western blot was used to verify the inhibition efficiency of HMGA2.
