Figure 3.
Reprogramming of m6A epitranscriptome upon hypoxic stress. (A) Heatmap representing enrichment scores for all methylated RNAs upon hypoxic stress (1% O2) for different durations. (B) Metagene profiles of enrichment of all m6A peaks across mRNA transcriptome. (C-E) Cumulative frequency of mRNA log2 FC for transcripts containing m6A located at 5ʹ UTR, CDS, 3ʹ UTR regions or non-methylated transcripts upon hypoxic stress. (F) Venn diagrams showing the number of either common m6A-hypo or m6A-hyper transcripts (|log2 (FC)| > 1) at all time points in response to oxygen deprivation (1% O2). (G) Gene ontology (GO) enrichment analysis of either common m6A-hypo or m6A-hyper genes in response to hypoxia (1% O2)