Table 2.
Characteristic and outcomes of patients with immunosupression.
| Mean value all ID patientsn=80 | Solid tumorn=42 | Hematological malignancyn=20 | Non neoplastic immunodeficiencyn=18 | P value | |
|---|---|---|---|---|---|
| Signs and symptoms at baseline | |||||
| Temperature°C | 37.7 (± 1.11) | 37.7 (± 1.09) | 37.6 (± 1.15) | 37.5 (± 1.11) | 0.8535 |
| Fever | 65 (81) | 36 (85) | 15 (75) | 14 (77) | 0.5475 |
| Respiratory rate | 21.8 (± 6.58) | 19.8 (± 4.51) | 24.8 (± 10.9) | 23.7 (± 5.05) | 0.0618 |
| Sao2 | 93.9 (± 2.69) | 94 (± 2.60) | 93.7 (±3.30) | 93.9 (± 2.31) | 0.0938 |
| Cough | 58 (72) | 33 (78) | 14 (70) | 11 (61) | 0.3660 |
| Shortness of breath | 28 (35) | 16 (38) | 5 (25) | 7 (38) | 0.555 |
| Abnormal auscultation | 49 (61) | 25 (59) | 12 (60) | 12 (66) | 0.8657 |
| Digestive symptoms (nausea/vomiting/diarrhea). | 24 (30) | 11 (26) | 6 (30) | 7 (38) | 0.6165 |
| Fatigue/syncope | 50 (62) | 34 (80) | 11 (55) | 15 (83) | 0.0571 |
| Biological status at baseline | |||||
| Hb | 11.9 (± 2.18) | 11.9 (±2.06) | 10.7 (±1.94) | 12.8 (±2.19) | 0.0093 |
| GB | 11.7 (± 21.7) | 6.24 (± 3.44)* | 26.0 (± 39.7)# | 7.36 (± 3.77) | 0.0061 |
| Ly | 4.35 (± 19.6) | 0.947(±0.485) | 14.5 (±38.6) | 1.05 (±0.454) | 0.0352 |
| ASAT | 57.5 (48.8) | 51.5(±33.5) | 49.6 (±48.3) | 73.7 (±68.9) | 0.2177 |
| ALAT | 41.4 (± 63.1) | 36.3 (±26.2) | 35.8 (±36.5) | 58.6 (±115) | 0.3681 |
| LDH | 366 (± 181) | 316 (±122) | 352 (±233) | 448 (±197) | 0.0475 |
| Bilirubin | 8.42 (± 3.85) | 8.55 (±4.10) | 8.24 (±3.55) | 8.33(±3.53) | 0.9575 |
| creatinine | 108 (± 113) | 119(±146) | 89.4(±38.9) | 96.0 (±56.2) | 0.5799 |
| CRP | 101 (± 84.2) | 98.1(±82.2) | 106(±90.1) | 103(±82.3) | 0.9398 |
| Ferritin | 1607 (± 1774) | 1470(±1628) | 2597(±2744) | 1371(±997) | 0.0929 |
| Fibrinogen | 6.10 (± 1.53) | 6.14(±1.33) | 5.87(±1.87) | 6.13(±1.57) | 0.8467 |
| D-dimer | 2060 (± 1873) | 1960(±1377) | 2512(±2569) | 1415(±1412) | 0.3092 |
| lactate | 1.70 (±0.922) | 1.65(±0.774) | 1.74(±1.41) | 1.75(±0.734) | 0.9497 |
| PaO2/FiO2 | 318(±90.5) | 316.29 (±84) | 309.22(±131) | 316.40 (±89) | 0.9755 |
| Treatment | |||||
| Steroids before admission | 16 (20) | 4 (9) | 2 (10) | 10 (55) | 0.0001 |
| Antibiotic | 50 (62) | 27 (64) | 12 (60) | 11 (61) | 0.9393 |
| Anticoagulation therapy | 56 (70) | 31 (73) | 13 (65) | 12 (66) | 0.7321 |
| Hydroxychloroquine | 9 (11) | 4 (9) | 1 (5) | 4 (22) | 0.2146 |
| Radiological findings | |||||
| CT-scan | 47 (58) | 21(50) | 14 (70) | 12 (66) | 0.2421 |
| Covid-19 pattern on CT-scan | 34 (42) | 16 (38) | 11 (55) | 7 (38) | 0.4256 |
| Extended lesions on CT-scan | 18 (22) | 6 (14) | 5 (25) | 7 (38) | 0.1070 |
| Pulmonary embolism | 6 (7) | 3 (7) | 1 (5) | 2 (11) | 0.7686 |
| Diagnosis of pneumonia | 64 (80) | 34 (80) | 14 (70) | 16 (88) | 0.3391 |
| 0utcomes | |||||
| ARDS | 33 (41) | 17 (40) | 7 (35) | 9 (50) | 0.6372 |
| ICU admission | 12 (15) | 3 (7) | 5 (25) | 4 (22) | 0.1143 |
| Death | 19 (23) | 8 (19) | 6 (30) | 5 (27) | 0.5754 |
| Poor outcome | 31 (38) | 11 (26) | 11 (55) | 9 (50) | 0.0823 |
⁎
p < 0.05 vs patients with hematological malignancy
#
p < 0.05 vs patients with non-neoplastic immunodeficiency
Abbreviations: Sa02: saturation of arterial blood with oxygen, Hb: hemoglobin, GB: white count cells, Ly: lymphocytes counts