Table 1. Summary of clinical features and immunohistochemistry of the 22 cases of soft tissue tumours with epithelioid morphology.
IHC: Immunohistochemistry; INI 1: Integrase interactor 1; EMA: Epithelial membrane antigen; HMB-45: Human melanoma black; DOG1: Discovered on GIST1
Diagnosis | Number of cases (n=22) | Age (years) | Site | Size (cm) | Positive IHC | Negative IHC |
Epithelioid Sarcoma (Conventional) | 3 | 27 to 47 | Lower extremities | 5 to 25 | Vimentin, cytokeratin and CD34 | S100, CD99, desmin, smooth muscle actin and INI 1 |
Epithelioid Sarcoma (Proximal type) | 2 | Upper extremities | ||||
Malignant Extrarenal Rhabdoid Tumour | 1 | 35 | Scapula | 4 | Vimentin, cytokeratin and CD99 | S100, desmin, CD34 and INI 1 |
Epithelioid malignant peripheral nerve sheath tumour | 2 | 63 and 50 | Chest and left leg | 6 and 12 | S-100 and vimentin | Cytokeratin, EMA, desmin, CD34, Melan-A and HMB-45 |
Epithelioid Leiomyosarcoma | 1 | 50 | Left leg | Smooth muscle actin and vimentin | Cytokeratin, CD34, S100, HMB-45 and CD117 | |
Epithelioid angiosarcoma | 3 | 40 to 65 | Lower extremities | 15 to 25 | CD31 and factor VIII | Cytokeratin, EMA and desmin |
Sclerosing epithelioid fibrosarcoma | 1 | 50 | Left knee | 12 | Vimentin | Cytokeratin, EMA, HMB45, desmin and alpha-smooth muscle actin |
Epithelioid myxofibrosarcoma | 3 | 43 to 45 | Lower extremities | 10 to 20 | - | All negative |
Epithelioid gastrointestinal stromal tumour | 2 | 48 and 58 | Stomach and ileum | 12 and 21 | CD117 and DOG1 | Cytokeratin, EMA, HMB45, desmin and alpha-smooth muscle actin |
Clear cell sarcoma | 2 | 17 and 35 | Left thigh and chest wall | 10 and 6 | HMB-45, neuron-specific enolase and S-100 | Cytokeratin, EMA, carcinoembryonic antigen, desmin, Melan-A and smooth muscle actin |
Monophasic synovial sarcoma | 1 | 50 | Inguinal region | 5 | Cytokeratin, EMA and vimentin | Smooth muscle actin, S100 and CD117 |
Malignant perivascular epithelioid cell tumour | 1 | 50 | Retroperitoneum | 8 | HMB45, Melan-A and actin | Cytokeratin, S100 and CD117 |