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. 2020 Dec 29;64(1):1–12. doi: 10.5468/ogs.20252

Table 2.

Results of the risk of bias assessment using the Newcastle-Ottawa Scale (NOS)

Author Study design Items for cohort studies Items for case controls Total NOS stars


Selection Comparability Outcome Selection Comparability Exposure






Representativeness of the exposed cohort Selection of the non-exposed cohort Ascertainment of exposure Demonstration that outcome of interest was not present at start of study Comparability of cohorts on the basis of the design or analysis controlled for confounders Assessment of outcome Was follow-up long enough for outcomes to occur Adequacy of follow up of cohorts Is the case definition adequate? Representativeness of the cases Selection of Controls Definition of Controls Comparability of cases and controls on the basis of the design or analysis Ascertainment of exposure Same method of ascertainment for cases and controls Non-Response rate
Brander et al. [18] Cohort * * * * ** * * ********

Browne et al. [11] Cohort * * * * ** * * ********

Mathews et al. [21] Cohort * * * * ** * * * *********

Leivonen et al. [12] Casecontrol * * * * ** * * ********

Motlagh et al. [22] Casecontrol * * * * ****

Pringsheim et al. [23] Casecontrol * * * * ** * * ********

Cubo et al. [24] Casecontrol * * * * * * * *******