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. 2020 Dec 6;296:100135. doi: 10.1074/jbc.REV120.015980

Figure 2.

Figure 2

Membrane-associated serine proteinases (MASPs): mosaic proteinases for cleavage of transmembrane and membrane-proximal substrates. Structural domains (approximate scale) are color-coded. Note the variety of noncatalytic scaffolds found in these mosaic proteinases, most notably in the matriptases (TMPRSS6, -7 and -14), corin/TMPRSS10, and enterokinase/TMPRSS15. In addition to type II transmembrane serine proteinases (TTSPs), type I or glycosylphosphatidylinositol (GPI)-anchored proteins that possess similar catalytic domains are also included (TMPRSS12/TMPSD, PRSS8/prostasin, PRSS21/testisin, PRS41/TESSP-1, and PRS55/T-SP1). CUB, complement C1r/C1s, Uegf, Bmp1; FRZ, frizzled; LDLR, low-density lipoprotein receptor; MAM, meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu; SEA, sea urchin sperm protein, enterokinase, agrin; SRCR, scavenger receptor cysteine-rich.