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The lifecycle of SARS-CoV-2. ACE2 receptor binding, endocytosis, viral genome translation, and amplification, followed by virion assembly and exocytosis. ACE2, angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane protease serine 2. (Reproduced with permission from Atri et al,48JACC Basic Transl Sci; 2020; 5(5):518-536.)
