Table 2. Dosages of anticoagulation regimens11 .
Anticoagulation regimen | Anticoagulation dosage |
---|---|
Prophylactic LMWH | • Enoxaparin, 40 mg SC once daily |
• Dalteparin, 5,000 units SC once daily | |
• Tinzaparin, 4,500 units SC once daily | |
• Nadroparin, 2,850 units SC once daily | |
Therapeutic LMWH | • Enoxaparin, 1 mg/kg SC every 12 hr |
• Daleparin, 200 units/kg SC once daily | |
• Dalteparin, 100 units/kg every 12 hours | |
• Tinzaparin, 175 units/kg once daily (target anti-Xa level in a therapeutic range of 0.6–1.0 units/mL 4 hr after last injection for twice-daily regimen) | |
Prophylactic UFH | • 5,000–7,000 units SC every 12 hr in the first trimester |
• 7,500–10,000 units SC every 12 hr in the second trimester | |
• 10,000 units SC every 12 hr in the second trimester unless aPTT is elevated | |
Therapeutic UFH | • 10,000 units or more SC every 12 hr in doses adjusted to target aPTT in the therapeutic range (1.5–2.5 × controls) 6 hr after injection |
LMWH = low molecular weight heparin, SC = subcutaneous, UFH = unfractionated heparin, aPTT = activated partial thromboplastin time.