Figure 3.

Additional clinical outcomes by CKD status at baseline. Data for randomized patients; HR and 95% CI from Cox proportional hazards model. CKD indicates chronic kidney disease; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HHF, hospitalization for heart failure; HR, hazard ratio; MedDRA, Medical Dictionary for Regulatory Activities; and UACR, urinary albumin-to-creatinine ratio. *Prevalent CKD defined as eGFR (CKD-EPI) <60 ml/min/1.73 m² or UACR >300 mg/g. †Composite exploratory endpoint included chronic dialysis or kidney transplant or sustained reduction of ≥40% in eGFR or sustained eGFR (CKD-EPI) <15 ml/min/1.73 m² (for patients with baseline eGFR ≥30) or sustained eGFR <10 (for patients with baseline eGFR <30). ‡Acute kidney injury based on MedDRA preferred term based on investigator-reported adverse events.