Figure S6.

Anamnestic immune response, lymphocyte counts, and emerged viral sequence variants in control and vaccinated cynomolgus macaques after SARS-CoV-2 challenge, related to Figure 6

(A) SARS-CoV-2 pseudovirus neutralization titers. The gray line represents the median titers over-time. (B) SARS-CoV-2 authentic virus neutralization titers. The gray line represents the median titers over-time. (C) Lymphocyte counts over time in the blood of control and SARS-CoV-2 S-I53-50NP vaccinated macaques after challenge. Vertical red dotted lines indicate the day of challenge. In (A)-(C) Symbols identify individual macaques as indicated Figure S5A. (D) Sum of viral variants found by viral sequencing, in nasopharyngeal swabs at 3 dpe and 5 dpe, and in BAL at 3 dpe, specified for the ORF in which it was found (top left) the type of nucleotide change (top right) and the effect is has on the amino acid sequence (bottom; missense_variant = amino acid change, synonymous_variant = no amino acid change, stop_gained = introduction of a stop codon). For a list of all identified variants see Table S3.